top of page
  • Jonathan Poyer

Pick the Best! Marginal or Failed Programs Not Attracting Additional Funding





The S&P select biotech index started the week trading above the 200 day moving average as it seemingly looks for a reason to breakout.



Specialists have been getting more optimistic as the biotech bear market nears the end of its ninth quarter. The American Society of Clinical Oncology (ASCO) meeting brought a number of data updates, but highlighted the challenges of comparing experimental cancer drugs across clinical trials.


Day One Biopharmaceuticals (DAWN) presenting updated data from the FIREFLY-1 trial that showed favorable results in pediatric low-grade glioma (pLGG). The stock was up nearly 40% premarket on Monday, but ended the day ~flat as investors debated the comparison to competitive products and potential regulatory scrutiny.



Likewise, the BCMA CAR-T space was hotly debated as several early programs demonstrated high response rates (up to 100% ORR), but questions remained on translation of the data to larger trials and potentially broader use outside of a few select treatment centers. Definitive data for potential IO combination partner TIGIT remained elusive as data updates at ASCO were incremental.


Investors are waiting for Roche's (RHHBY) Phase III SKYSCRAPER-01 study showcasing anti-TIGIT tiragolumab in NSCLC later this year for a more definitive read on the combination.



Drug pricing remained in the headlines as Coherus Biosciences (CHRS) announced plans to launch a biosimilar Abbvie's (ABBV) Humira at an 85% discount to the branded price. Humira was the world's best selling drug at its peak and not-surprisingly ABBV hit a 52-week low on the news.



Creative destruction continued as both Novan (NOVN) and Greenlight Biosciences (GRNA) announced 50% reductions in force.



Bellerophon (BLPH) fell nearly 90% upon announcing the Phase 3 REBUILD trial did not meet its primary endpoint. Notable, the INOpulse intervention group actually performed worse than the placebo group. BLPH raised $5 million in early March at $2 and the stock ran to $12 in April before closing below $1 on the negative trial outcome.



The decline in the number of publicly traded biotech companies is expected to continue as marginal or failed programs fail to attract additional funding.

10 views0 comments

Commenti


bottom of page